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57,58 Impaired translocation of intracellular GSV (GLUT4 storage vesicles) caused decreased insulin-stimulated glucose uptake which are associated with IR in muscle and adipose tissues

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This study showed that chronic peripheral administration of liraglutide to Phox2b-Cre Glp1r flox/flox mice fed a HFD reduced food intake, body weight, and adiposity suggesting that the PNS is not required for liraglutide to mediate its effects on energy metabolism

Increased percentage of TMCA could also be observed in the feces of MMI + T3-5d mice compared to MMI mice (Fig

doi: 10.3389/fcimb.2022.861703 101 NaendrupJHGarcia BorregaJEichenauerDAShimabukuro-VornhagenAKochanekMBllB

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